MEG

MEG Research at the SPMMRC

The SPMMRC, in collaboration with departments of Psychology, Psychiatry, Academic Radiology, the Institute of Hearing Research and Food Science, have installed a £1.4m MEG system. This machine is installed close to the 7T MRI scanner.

The MEG group within the SPMMRC are:
Peter Morris
Johanna Zumer
Claire Stevenson
Matt Brookes
Joanne Hale
Fan Wang
Jonathan Wood
Tom White

The two systems in tandem will allow for measurement of brain activity with extremely high temporal (using MEG) and spatial (using MRI) resolution.

Magnetoencephalography (MEG) allows direct measurement of neuronal activity by sampling magnetic fields generated outside the head by neuronal currents in the brain. Detection of these tiny (~10fT) magnetic fields is made possible by the use of superconducting quantum interference devices (SQUID's). MEG measurements of brain activity complement those made by BOLD fMRI, which provide an indirect means of mapping human brain function since the measured haemodynamic response is related to activation-induced increases in metabolic demand.

The magnetoencephalogram recorded from a patient suffering from a scintillating scotoma (a visual disturbance associated with migraine). Recorded data show significant increases and decreases of gamma band activity in the temporal and frontal lobes respectively. (The colour scale shows measures T-statistic)

Publications

Investigating spatial specificity and data averaging in MEG : A retinotopic mapping study
M.J.Brookes, J.M.Zumer, C.M.Stevenson, J.R.Hale, G.R.Barnes, J.Vrba, P.G.Morris.
Neuroimage, In Press 

Understanding gradient artefacts in simultaneous EEG/fMRI
W.X.Yan, K.J.Mullinger, M.J. Brookes , R. Bowtell
NeuroImage , 46: 459-471 (2009)

Source localisation in concurrent EEG/fMRI: Applications at 7T
M.J. Brookes , J.Vrba, K.J.Mullinger, G.B.Geirsdóttir, W.X.Yan, C.M.Stevenson, R.Bowtell, P.G.Morris
NeuroImage , 45: 440-452 (2009)

Beamformer Imaging and Interference Rejection
M.J.Brookes, C.M.Stevenson, A.Hadgipapas, G.R.Barnes, K.J.Mullinger, A.P.Bagshaw, R.Bowtell, P.G.Morris, Jiri Vrba
In Boimagnetism. Interdisiplinary research and exploration.
Editors: R. Kakigi, K.Yokosawa, S.Kuriki (ISBN 978-4-8329-0355-5)
Hokkaido University Press (2008)

Modulation of the MEG sustained field by a controlled hypercapnic stimulus
N.P.Blockley, T.P.White, C.M.Stevenson, M.J.Brookes, S.T.Francis, P.A.Gowland, P.G.Morris
In Boimagnetism. Interdisiplinary research and exploration.
Editors: R. Kakigi, K.Yokosawa, S.Kuriki (ISBN 978-4-8329-0355-5)
Hokkaido University Press (2008)

Adaptive beamformer processing of visceral pain processing
T.P.White, D.Humes, M.J.Brookes, L.Marciani, D.Bush, J.Smith, S.T.Francis, K.E.Head, J.Simpson, C.M.Stevenson, P.A.Gowland, P.G.Morris, R.C.Spiller
In Boimagnetism. Interdisiplinary research and exploration.
Editors: R. Kakigi, K.Yokosawa, S.Kuriki (ISBN 978-4-8329-0355-5)
Hokkaido University Press (2008)

Simultaneous EEG source localisation and artifact rejection during concurrent fMRI by means of spatial filtering
M.J.Brookes, K.J.Mullinger, C.M.Stevenson,P.G.Morris, R.W.Bowtell
Neuroimage. 40 1090-1104 (2008)

Optimising experimental design for MEG beamformer imaging
M.J.Brookes, S.E.Robinson, J.Vrba, C.M. Stevenson, A.M.Peters, G.R. Barnes, A. Hillebrand and P.G. Morris.
Neuroimage. 39 1788-1802 (2008)

High field (7 Tesla) MRI determines multiple sclerosis lesions heterogeneity in vivo
Neuromagnetic Correlates of the fMRI BOLD response
C.M.Stevenson, M.J.Brookes, G.R.Barnes, A.Hillebrand, S.T.Francis and P.G.Morris
International congress series 1300: 325-328 (2007)

Beamformer reconstruction of correlated sources using a modified source model
M.J. Brookes, C.M. Stevenson, G.R. Barnes, A. Hillebrand, M.I.G. Simpson, S.T. Francis and P.G. Morris .
NeuroImage 34: 1454-1465 (2007)

GLM -Beamformer Method Demonstrates Stationary Field, Alpha ERD and Gamma ERS Co-Localisation with fMRI Bold Response In Visual Cortex
M.J.Brookes, A.M.Gibson, S.D.Hall , P.L.Furlong, G.R.Barnes, A. Hillebrand, K.D. K.D.Singh, I.E.Holliday, S.T.Francis and P.G.Morris
NeuroImage 26: 302 – 308 (2005)

A General Linear Model for MEG Beamformer Imaging
M.J.Brookes, A.M.Gibson, S.D.Hall , P.L.Furlong, G.R.Barnes, A. Hillebrand, K.D. K.D.Singh, I.E.Holliday, S.T.Francis and P.G.Morris
NeuroImage 23 (3): 936-946 (2004) 

MEG related Conference Abstracts 

Imaging Non-Stationary brain sources using MEG
M.J.Brookes, C.M.Stevenson, J.M.Zumer, P.G.Morris
Proc. 15 th annual meeting of OHBM, San Francisco , June 2009

Deconvolved fMRI correlates with source-localised MEG as a function of neural frequency oscillation
J.M.Zumer, C.M.Stevenson, M.J.Brookes, S.T.Francis, P.G.Morris
Proc. 15 th annual meeting of OHBM, San Francisco , June 2009

Role of beta-band oscillations in somatosensory cortex measured using MEG
F.Wang, C.M.Stevenson, J.M.Zumer, T.P.White, M.J.Brookes, P.G.Morris
Proc. 15 th annual meeting of OHBM, San Francisco , June 2009 

Optimising experimental design for MEG connectivity analysis using DICS
J.Hale, M.J.Brookes, J.M.Zumer, C.M.Stevenson, P.G.Morris
Proc. 15 th annual meeting of OHBM, San Francisco , June 2009

The relationship between 7T fMRI BOLD and MEG derived ? activity
C.M.Stevenson, M.J.Brookes, P.G.Morris.
Proc. 17 th annual meeting of ISMRM, Honolulu , April 2009

A comparison of quantitative perfusion measu rem ents and MEG phenomena
C.M.Stevenson, M.J.Brookes, P.G.Morris, S.T.Francis.
Proc. 17 th annual meeting of ISMRM, Honolulu , April 2009

Deconvolved fMRI correlates with source-localised MEG as a function of neural frequency oscillation
J.M.Zumer, C.M.Stevenson, M.J.Brookes, S.T.Francis, P.G.Morris.
Proc. 17 th annual meeting of ISMRM, Honolulu , April 2009

Cortical responses to a rectal balloon pain paradigm
L.Marciani, D.Humes, K.Head, T.White, J.Smith, D.Bush, M.Brookes, C.Stevenson, P.G.Morris, R.C.Spiller, P.A.Gowland, S.T.Francis.
Proc. 17 th annual meeting of ISMRM, Honolulu , April 2009

Exploring cognitive control using adaptive beamforming techniques
T. White, D. Astle, M. Brookes, M. Schuermann, S. Jackson , G. Jackson
16 th International conference on biomagnetism, Sapporo , 2008

The relationship between MEG and fMRI: Visual contrast response
C.M. Stevenson, M.J. Brookes, P.G. Morris
16 th International conference on biomagnetism, Sapporo , 2008

Adaptive beamformer analysis of visceral pain processing
T. White, D. Humes, M. Brookes, D. Bush, L. Marciani, S. Francis, J. Simpson, C. Stevenson, P. Gowland, P. Morris, R. Spiller
16 th International conference on biomagnetism, Sapporo , 2008

Beta Band Correlates of the fMRI BOLD response
C. Stevenson, M.J. Brookes, P.G. Morris
16 th International conference on biomagnetism, Sapporo , 2008

A comparison of quantitative perfusion imaging and MEG phenomena
C. Stevenson, M.J. Brookes, P.G. Morris, S.T. Francis
16 th International conference on biomagnetism, Sapporo , 2008

Beamformer Imaging: Optimising Estimation of Data Covariace
M. Brookes, J. Vrba, S.E. Robinson, C.M. Stevenson, G.R. Barnes, A. Hillebrand, P.G. Morris
16 th International conference on biomagnetism, Sapporo , 2008

An analytical model of beamformer interference suppression
M. Brookes, C.M. Stevenson, P.G. Morris, J. Vrba
16 th International conference on biomagnetism, Sapporo , 2008

Modulation of the MEG sustained field by a controlled hypercapnic stimulus
N.P. Blockley, T.P. White, C.M. Stevenson, M.J. Brookes, P.G. Morris
16 th International conference on biomagnetism, Sapporo , 2008

Signal Processing Techniques for Multimodality Studies
M. Brookes, C.M. Stevenson, K.J. Mullinger, G. Geirsdottir, J. Vrba, R. Bowtell, P. G. Morris
16 th International conference on biomagnetism, Sapporo , 2008

Comparing MEG source localization algorithms with fMRI statistical maps and neuroanatomy
J.M. Zumer, E. Disbrow, H. Attias, M.J. Brookes, P.G. Morris, S. Nagarajan
Proc. 14 th annual meeting of OHBM, Melbourne June 2008

Measurem ent of gamma band effects in MEG and concurrent EEG/fMRI at 7T
M.J. Brookes, K.J. Mullinger, C.M. Stevenson, G. Geirsdottir, P.G. Morris, R. Bowtell
Proc. 14 th annual meeting of OHBM, Melbourne June 2008

Improved artifact rejection for simultaneous EEG/fMRI at 7T using a high EEG channel density and a vector beamformer
M.J. Brookes, K.J. Mullinger, G.B. Geirsdottir, C.M. Stevenson, P.G. Morris, and R.W. Bowtell
Proc. 16 th annual meeting of ISMRM, Toronto , May 2008

Electrical and haemodynamic effects measured using MEG and combined EEG/fMRI
M.J.Brookes, K.J.Mullinger, C.M.Stevenson, G.B.Geirsdottir, R.W.Bowtell, and P.G.Morris
Proc. 16 th annual meeting of ISMRM, Toronto , May 2008

The relationship between the fMRI BOLD response and beta band neuromagnetic effects
C.M.Stevenson, M.J.Brookes, and P.G.Morris
Proc. 16 th annual meeting of ISMRM, Toronto , May 2008

The relationship between fMRI and MEG : Visual contrast response
C.M.Stevenson, M.J.Brookes, and P.G.Morris
Proc. 16 th annual meeting of ISMRM, Toronto , May 2008

Exploring the relationship between natural fluctuations in electrical measures of brain activity and the BOLD response during visual stimulation.
K.J.Mullinger, G.B.Geirsdottir, M.J.Brookes, P.F.Liddle, and R.W.Bowtell
Proc. 16 th annual meeting of ISMRM, Toronto , May 2008

Assessment of BOLD signal adaptation using single event fMRI at 7 T and its correlation with MEG
P.J.Wright, M.J.Brookes, J.E.Dixon, P.G.Morris, P.A.Gowland, and S.T.Francis
Proc. 16 th annual meeting of ISMRM, Toronto , May 2008

Neuromagnetic correlates of the 7T BOLD Response in Visual Cortex
M.J.Brookes, C. M. Stevenson, A. Hillebrand, G. R. Barnes, J. W. Peirce, and P. G. Morris
Proc. 15 th annual meeting of ISMRM, Berlin , May 2007

Linearity of the BOLD response: A comparison between fMRI and MEG
C.M.Stevenson, M.J.Brookes, G.R.Barnes, A.Hillebrand, S.T.Francis and P.G.Morris
Proc. 15 th annual meeting of ISMRM, Berlin , May 2007

A dual source approach to MEG beamformer imaging
M.J.Brookes, C.M.Stevenson, M.I.G.Simpson, G.R.Barnes, A.Hillebrand, S.T.Francis and P.G.Morris.
15 th International conference on biomagnetism, Vancouver , 2006

Neuromagnetic correlates to the BOLD response
C.M.Stevenson, M.J.Brookes, G.R.Barnes, A.Hillebrand, S.T.Francis and P.G.Morris
15 th International conference on biomagnetism, Vancouver , 2006

Spatial extent of neuronal activity measured with MEG beamformers
A. Hillebrand, M.J.Brookes, K.D.Singh, P.L.Furlong, G.R.Barnes
Proc. 10 th Annual meeting of OHBM, Toronto , June 2005.

MEG functional co-registration to anatomy
G.R.Barnes, K.D.Singh, P.Adjamian, M.J.Brookes, A.Hillebrand
Proc. 10 th Annual meeting of OHBM, Toronto , June 2005.

Neuronal Basis of the BOLD Effect Investigated Using MEG
M.J.Brookes, S.Hall, P.L.Furlong, G.R.Barnes, A.Hillebrand, K.D.Singh, I.E.Holliday, S.Francis and P.G.Morris
Proc. 13 th annual meeting of ISMRM, Miami May 2005

A General Linear Model for MEG Beamformer Imaging
M.J.Brookes, A.M.Gibson, S.D.Hall , P.L.Furlong, G.R.Barnes, A.Hillebrand, K.D.Singh, I.E.Holliday, S.T.Francis and P.G.Morris
Proc. 10 th annual meeting of OHBM, Budapest June 2004

MEG Correlates of the fMRI BOLD Response to Visual Stimulation
M.J.Brookes, A.M.Gibson, S.D.Hall , P.L.Furlong, G.R.Barnes, A.Hillebrand, K.D.Singh, I.E.Holliday, S.T.Francis and P.G.Morris
Proc. 10 th annual meeting of OHBM, Budapest June 2004

New Processing Methods for Magnetoencephalographic ( MEG ) data reveal Neuronal Correlates to the BOLD response
M.J.Brookes, A.M.Gibson, S.D.Hall , P.L.Furlong, G.R.Barnes, A.Hillebrand, K.D.Singh, I.E.Holliday, S.T.Francis and P.G.Morris
Proc. 12 th annual meeting of ISMRM, Kyoto May 2004.

The fMRI BOLD Response Co-varies Spatially and Temporally with Electrical oscillatory Change and a Sustained Electrical Response
M.J.Brookes, A.M.Gibson, S.D.Hall , P.L.Furlong, G.R.Barnes, A.Hillebrand, K.D.Singh, I.E.Holliday, S.T.Francis and P.G.Morris
Proc. 12 th annual meeting of ISMRM, Kyoto May 2004.