Modelling and measuring brain haemodynamics

In the brain, neuronal activity is thought to cause a local increase in blood flow (CBF), which leads to an increase in blood oxygenation and blood volume (CBV). In order to be able to accurately relate our fMRI data to neuronal activity, and to better understand fMRI signal changes, it is important to measure these parameters simultaneously and quickly. We have developed and optimised methods of simultaneously measuring CBV and CBF with high temporal resolution. We have also developed a method of measuring the change in blood oxygenation. We are currently investigating methods of separating the arterial and venous effects.